Each film-coated tablet contains
Clithrocin is indicated for the treatment of mild to moderate
infections due to susceptible organisms. Upper respiratory tract
infections Pharyngitis, tonsillitis. Lower respiratory tract
infections Acute and chronic bronchitis, pneumonia Uncomplicated
skin and skin structure infections like Folliculitis, Cellulitis,
macrolide antibiotic similar to erythromycin and azithromycin, is
effective against Mycobacterium avium complex (MAC) and is used
for the treatment of Helicobacter pylori-associated peptic
ulcer disease, community-acquired pneumonia, sinusitis, and
chronic bronchitis. Clarithromycin is also used to treat
respiratory tract, sexually transmitted, otitis media, and
AIDS-related infections. For the treatment of Bacterial infection
of (Pharyngitis/Tonsillitis, sinusitis, bronchitis, Pneumonia,
Uncomplicated skin and skin structure infections ) caused by
H.influenzae, M.catarrhalis, M.pneumoniae, S.pneumoniae,
C.pneumoniae (TWAR), S.aureus.
first metabolized to 14-OH clarithromycin. Like other macrolides,
it then binds to the 50 S subunit of the 70 S ribosome of the
bacteria, blocking RNA-mediated bacterial protein synthesis.
Clarithromycin also inhibits the hepatic microsomal CYP3A4
isoenzyme and P-glycoprotein, an energy-dependent drug efflux
contraindicated in patients with a known hypersensitivity to
clarithromycin, erythromycin, or any of the macrolide antibiotics.
Concomitant administration of clarithromycin with cisapride,
pimozide, or terfenadine is contraindicated. There have been
post-marketing reports of drug interactions when clarithromycin
and/or erythromycin are co-administered with cisapride, pimozide,
or terfenadine resulting in cardiac arrhythmias (QT prolongation,
ventricular tachycardia, ventricular fibrillation, and torsades de
pointes) most likely due to inhibition of hepatic metabolism of
these drugs by erythromycin and clarithromycin.
Adults: Children >
The usual dose is
one tablet (250 mg) twice daily for 7 days, although this may be
increased to two tablets (500 mg) twice daily for up to 14 days in
Children less than 12 years: 7.5 mg/kg every 12 hours for 10 days.