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Composition
Elemental Calcium..............................................250
mg
Vitamin
D3............................................................125
I.U
Indications
Calcium Ostrong tablets are indicated as a basic dietary supplement. As a prophylactic treatment of the relevant vitamin and mineral
deficiency states during pregnancy and/or lactation. Calcium with
Magnesium is necessary for the development of strong bones and
teeth, also prevents muscle cramping, risk of colon cancer,
maintain regular heart beat, protect against osteoporosis and
helps relax the central nervous system with added zinc.
Description
Calcium is absorbed from the small intestine by both active and
passive mechanisms. At low and moderate intakes of calcium,
calcium is absorbed via active transfer. Active transfer depends
on the action of the active form of vitamin
D,1,25-dihydroxycholecalciferol or 1,25(OH)2 D3. Vitamin D-induced
calcium transport involves the synthesis of the calcium-binding
protein, calbindin. Calbindin serves as a calcium translocator. It
also serves as a cytosolic calcium buffer. Calcium is typically
freed from calcium complexes during digestion and is released in a
soluble and probably ionized form for absorption. Low molecular
weight complexes, such as calcium carbonate, may be absorbed
intact.
As calcium intakes increase, the active transfer mechanism becomes
saturated and an increasing proportion of calcium is absorbed via
passive diffusion.
The absorption efficiency of calcium varies throughout the life
span. It is highest during infancy when it is about 60%. In
prepubertal children, it is about 28%. During early puberty, at
the time of the growth spurt, it increases to about 34% and then
drops to 25% two years later where it remains for several years.
Absorption efficacy increases during the last two trimesters of
pregnancy. It does decline with aging. In postmenopausal women,
fractional absorption of calcium declines on the average of 0.21%
yearly. Men lose absorption efficiency at about the same rate as
women.
Absorption efficiency appears to vary with the different calcium
complexes. In one study, absorption efficiency from a 250
milligram dose of calcium citrate malate was found to be 35%; from
calcium carbonate, 27%; and from tricalcium phosphate, 25%. For
comparison, calcium absorption efficiency from milk was found to
be 29%. Some, but not all, studies suggest that calcium is more
efficiently absorbed from calcium citrate and calcium citrate
malate than it is from calcium carbonate. The efficiency of
absorption of calcium from a calcium supplement is greatest when
calcium is taken at doses of 500 milligrams or lower. Individuals
with achlorhydria absorb calcium from calcium carbonate poorly
unless the calcium carbonate supplement is taken with food.
Calcium that is unabsorbed from the intestine is excreted in the
feces. Greater than 98% of calcium from the glomerular filtrate is
reabsorbed. Renal reabsorption is primarily regulated by
parathyroid hormone or PTH.
Approximately 40% of calcium in the plasma is bound to proteins,
primarily albumin; about 50% of calcium in the plasma is
diffusible ionic calcium and about 10% is diffusible, but is
complexed with such anions as phosphate and citrate.
CONTRAINDICATIONS
Calcium supplementation is contraindicated in those with
hypercalcemia. Conditions causing hypercalcemia include
sarcoidosis, hyperparathyroidism, hypervitaminosis D and cancer.
Calcium supplementation is contraindicated in those hypersensitive
to any component of a calcium-containing supplement.
PRECAUTIONS
Supplemental calcium taken without food may increase the risk of
kidney stones in women and possibly also in men. It is thought
that taking supplemental calcium without food limits the
opportunity for the beneficial effect that calcium may have in
binding oxalate in the intestine. Therefore, it is advisable that
supplemental calcium be taken with food.Those who form
calcium-containing kidney stones are generally advised not to take
supplemental calcium.
Dosage
As per the physician’s advice
Presentations
10 tablets
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Quality
