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Composition :
Alfuzosin Tablets
Each tablet contains Alfuzosin hydrochloride (extended release)
10mg
Indication
Alfuzosin (alfuzosin HCl 10 mg extended-release tablets) is an
alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information :
Do not take Alfuzosin if you have liver problems or if you are
taking antifungal drugs like ketoconazole or itraconazole, or HIV
drugs like ritonavir.
Alfuzosin can cause a sudden drop in blood pressure, especially
when starting treatment. This may lead to fainting, dizziness, and
lightheadedness. Do not drive, operate machinery, or do any
dangerous activity until you know how Alfuzosin will affect you.
This is especially important if you already have a problem with
low blood pressure or take medicines to treat high blood pressure.
There may be an increased risk of low blood pressure and fainting
when taking Alfuzosin in combination with blood pressure
medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your
eye surgeon that you are currently taking Alfuzosin or have
previously been treated with an alpha-blocker.
Before taking Alfuzosin, tell your doctor if you have kidney
problems.
Also, tell your doctor if you or any family member(s) have or take
medications for a rare heart condition known as congenital
prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However,
Alfuzosin is not a treatment for prostate cancer.
The most common side effects with Alfuzosin are dizziness, upper
respiratory tract infection, headache, and tiredness.
Indications :
Alfuzosin is used to treat symptoms of benign prostatic
hyperplasia (BPH, enlarged prostate) such as frequent, urgent need
to urinate during the day and at night, weak urine stream, and
difficulty urinating. Alfuzosin is in a class of medications
called alpha-1 blockers. It works by relaxing the muscles in the
prostate and bladder neck to allow urine to flow more easily.
Description
Alpha blocker drug ,relax the muscles in the prostrate gland and
the neck of the bladder.This allows the urethra to open wider so
that urine flows more easily.
Contraindications :
Alfuzosin should be used with caution in patients with severe
renal insufficiency, and should not be prescribed to patients with
a known history of QT prolongation or to patients who are taking
medications known to prolong the QT interval (term related to
cardiology). Alfuzosin should not be used in patients with
moderate or severe hepatic insufficiency, (Childs-Pugh categories
B and C) since alfuzosin blood levels are increased in these
patients. Alfuzosin should not be co-administered with potent
CYP3A4 inhibitors such as ketoconazole, itraconazole, and
ritonavir, since alfuzosin blood levels are increased. Alfuzosin
is contraindicated in patients known to be hypersensitive to
alfuzosin hydrochloride or any component of Alfuzosin tablets.
During cataract surgery, a variant of small pupil syndrome known
as
Intraoperative Floppy Iris Syndrome (IFIS) has been reported in
some patients on
or previously treated with alpha-1 blockers.
Overdosage :
Should overdose of ALFUSIN lead to hypotension, support of the
cardiovascular system is of first importance. Restoration of blood
pressure and normalization of heart rate may be accomplished by
keeping the patient in the supine position. If this measure is
inadequate, then the administration of intravenous fluids should
be considered. If necessary, vasopressors should then be used and
the renal function should be monitored and supported as needed.
Alfuzosin is 82% to 90% protein-bound; therefore, dialysis may not
be of benefit.
Side effects :
The most common side effects are dizziness (due to postural
hypotension), upper respiratory tract infection, headache, and
fatigue.
Alfuzosine : Blister pack of 10
capsules
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