Tetrazin® (tetrabenazine) Tablets
Tetrazin® (tetrabenazine) Tablets are used to
treat the involuntary movements (chorea) of Huntington’s
disease. Tetrazin® does not cure the cause of the involuntary
movements, and it does not treat other symptoms of Huntington’s
disease, such as problems with thinking or emotions. It is not
known whether tetrabenazine is safe and effective in children.
Before You Start
Before you start taking Tetrazin®,
you should tell your doctor about all of the prescription
medications as well as non-prescription medicines, vitamins,
herbal products or other supplements you are taking. Tetrazin®
may interact with some of these medications. Make sure you tell
your doctor before you start or stop any new medication, or if
you change the dose of any medication or supplements you are
taking. Always read the Medication Guide before starting your
treatment with Tetrazin®. If you have any questions regarding
Tetrazin®, be sure to talk with your doctor.
How to Take
(tetrabenazine) is a tablet you swallow. You can take it with or
without food. Tetrazin® comes in two different tablet strengths,
12.5 milligrams (mg) and 25 mg.
always take Tetrazin® as prescribed by your doctor. Depending on
you or your loved one’s condition and previous history with
taking Tetrazin®, your doctor will start slowly and may increase
the strength and number of tablets (dose) you take over the
course of several weeks up to a few months.
The process of
slowly increasing your dose is also known as titration. Your
doctor may give you a dosing schedule to help you keep track of
when and how much Tetrazin® to take.
Tetrazin®, it is important to remain patient since it may take
awhile for your physician to find the right dose that works for
you. During this time, you may experience some side effects, so
be sure to communicate with your doctor about how you are
feeling. Your doctor may adjust your dose.
doctor if you stop taking Tetrazin® for more than 5 days. Do not
take another dose until you talk to your doctor. If your doctor
thinks you need to take more than
50 mg of
Tetrazin® each day, you will need to have a blood test to see if
you should be taking Tetrazin®.
attention to any changes, especially sudden changes, in mood,
behaviors, thoughts or feelings or worsening depression. This is
especially important when Tetrazin® is started or when the dose
Tetrazin® is Not
Suitable for Everyone
Some people should not take Tetrazin®.
Tetrazin® can increase the chance of depression, suicidal
thoughts, or suicidal actions in some patients.
Do not take Tetrazin® if:
You are sad (depressed) much of the time. You can become
more depressed taking Tetrazin®.
You take medicine for depression, but it is not well
You think or talk about harming yourself or killing yourself
(suicide.) You may be more likely to think about ending your
life while taking Tetrazin®.
You have liver problems.
You take a monoamine oxidase inhibitor (MAOI), reserpine, or
a medicine that contains reserpine. If your doctor plans to
switch you from taking reserpine to Tetrazin®, you must wait
at least 20 days after your last dose of reserpine before
you start taking Tetrazin®. Ask your doctor or pharmacist if
you are not sure.
When taking Tetrazin®, pay close
attention to any changes in how you feel. Let your doctor know
if you have sudden changes in your mood, behaviors, or thoughts.
These changes may occur when you start Tetrazin® and when your
doctor changes your dose.
TETRAZIN® can cause serious side
Depression, suicidal thoughts, or actions. See "What
is the most important information I should know about
Neuroleptic Malignant Syndrome (NMS). Call your
doctor right away and go to the nearest emergency room if
you develop these signs and symptoms that do not have
another obvious cause:
very fast or uneven heartbeat
Parkinsonism. Symptoms of parkinsonism include:
slight shaking, body stiffness, trouble moving or keeping
Restlessness. You may get a condition where you feel
a strong urge to move. This is called akathisia.
Trouble swallowing. Tetrazin® may increase the chance
that you will have trouble swallowing. Increased coughing
may be the first sign that you are having trouble
swallowing. Trouble swallowing increases your risk of
Irregular heartbeat. Tetrazin® increases your chance
of having certain changes in the electrical activity in your
heart which can be seen on an electrocardiogram (EKG). These
changes can lead to a dangerous abnormal heartbeat. Taking
Tetrazin® with certain medicines may increase this chance.
Dizziness due to blood pressure changes when you change
position (orthostatic hypotension). Change positions
slowly from lying down to sitting up and from sitting up to
standing when taking Tetrazin®. Tell your doctor right away
if you get dizzy or faint while taking Tetrazin®. Your
doctor may need to watch your blood pressure closely.
Tardive dyskinesia (TD). TD is a condition where
there is repeated facial grimacing that cannot be
controlled, sticking out of the tongue, smacking of the
lips, puckering and pursing of the lips, and rapid eye
blinking. Tetrazin® works like other drugs that can cause
TD. If you get TD with Tetrazin®, it is possible that the TD
will not go away.
Common side effects with
Tell your doctor if you have any
side effects. Do not stop taking Tetrazin® without talking to
your doctor first.
Call your doctor for medical
advice about side effects. You may report side effects to the
Food and Drug Administration (FDA) at 1-800-FDA-1088.
Indications and Usage:
is a medicine that is used to treat the involuntary movements
(chorea) of Huntington’s disease. TETRAZIN® does not cure the
cause of the involuntary movements, and it does not treat other
symptoms of Huntington’s disease, such as problems with thinking
It is not known whether TETRAZIN®
is safe and effective in children.
can cause serious side effects, including:
not start taking TETRAZIN® if you are depressed (have
untreated depression or depression that is not well
controlled by medicine) or have suicidal thoughts.
attention to any changes, especially sudden changes, in
mood, behaviors, thoughts or feelings, or worsening
depression. This is especially important when TETRAZIN® is
started and when the dose is changed.
Some side effects, such as depression, tiredness, trouble
sleeping, sleepiness, parkinsonism, agitation, and restlessness
(akathisia), may be dose-dependent. If the side effects don’t
stop or lessen, your doctor should consider lowering the dose or
stopping your TETRAZIN®. The most commonly reported side effects
in studies with TETRAZIN® were sleepiness, trouble sleeping,
depression, tiredness, anxiety, restlessness, agitation and
Do not take
TETRAZIN® if you have liver problems or are taking monoamine
oxidase inhibitors or reserpine. Ask your doctor or
pharmacist if you are not sure. At least 20 days should
pass after stopping reserpine before starting TETRAZIN®.
doctor if you are pregnant, breast-feeding or have breast
cancer. Do not start any new medicines while
taking TETRAZIN® without talking to your doctor first.
for therapy should be evaluated on an ongoing basis with
your doctor. The dose of TETRAZIN® should be adjusted slowly
over several weeks for a dose that is appropriate for you.
Tell your doctor if you stop taking TETRAZIN® for more than
5 days. Do not take another dose until you talk to
your doctor. If your doctor thinks you need to take more
than 50 mg of TETRAZIN® each day, you will need to have a
blood test to see if a higher dose is right for you.
Malignant Syndrome (NMS) is a potentially fatal side effect
reported with TETRAZIN®. Call your doctor right away and go
to the nearest emergency room if you develop these signs and
symptoms that do not have another obvious cause: high fever,
stiff muscles, problems thinking, very fast or uneven
heartbeat, or increased sweating. TETRAZIN® should be
stopped immediately if NMS is diagnosed.
can also cause other serious side effects, including:
parkinsonism (slight shaking, body stiffness, trouble moving
or keeping your balance), restlessness (akathisia), trouble
swallowing, irregular heartbeat, and dizziness due to blood
pressure changes when you change position (orthostatic
hypotension). Trouble swallowing may increase the risk of
pneumonia. Uncontrolled movements called tardive dyskinesia
(TD) may also develop in patients treated with TETRAZIN®. It
is possible that the TD will not go away.
effects such as irregular heartbeat, NMS, and parkinsonism,
may be increased when using TETRAZIN® with other drugs
(e.g., dopamine antagonists).
is a common side effect of TETRAZIN®; do not drive a car
or operate dangerous machinery until you know how TETRAZIN®
affects you. Alcohol and other drugs may increase
sleepiness caused by TETRAZIN®.
TETRAZIN® is a registered
trademark of Taj Pharma India