Composition

Humogen® A.I.T (Advance Infertility Treatments) HCG Chorionic Gonadotropin for Injection USP 2000i.u. /5000i.i. & 10000i.u.
Substantion: Chorionic Gonadotrophin (HCG)
Manufacturer: Taj Pharmaceuticals Ltd, India
(pharmacy production)
Pack: 1 amp. 2000i.u.,5000i.u & 10000 + 1 amp. a 1ml solvent
Active Life: 64 hours
Drug Class: Leutenizing Hormone (LH) - Gonadotropin
Average Dose: debatable
Acne: Yes
Water Retention: Yes
High Blood Pressure: Yes
Liver Toxic: No

THIS MEDICATION IS A HORMONE USED IN BOYS (BEFORE PUBERTY) TO CAUSE THE NORMAL DROPPING OF THE TESTICLES INTO THE SCROTUM. IT IS ALSO USED IN CERTAIN BOYS TO HELP WITH NORMAL SEXUAL DEVELOPMENT. IT WORKS BY CAUSING THE TESTES TO RELEASE MALE SEX HORMONES (E.G., TESTOSTERONE). THIS MEDICATION IS ALSO USED IN WOMEN TO TREAT FERTILITY PROBLEMS. IT IS GIVEN AFTER FINISHING ANOTHER MEDICATION (MENOTROPINS) TO CAUSE THE RELEASE OF AN EGG (OVULATION). IT SHOULD NOT BE USED IN WOMEN WHOSE OVARIES NO LONGER MAKE EGGS PROPERLY (PRIMARY OVARIAN FAILURE).THIS MEDICATION HAS NOT BEEN SHOWN TO BE EFFECTIVE FOR WEIGHT LOSS AND SHOULD NOT BE USED FOR THIS PURPOSE.

Aromatization: No, but it will raise testosterone levels and increased aromatization may occur.
Chorionic gonadotropin is a hormone found in the female body during the early months of pregnancy (it is produced in the placenta). It is in fact the pregnancy indicator looked at by the over the counter pregnancy test kits, as due to its origin it is not found in the body at any other time. Blood levels of this hormone will become noticeable as early as seven days after ovulation. The level will rise evenly, reaching a peak at approximately two to three months into gestation. After this point, the hormone level will drop gradually until the point of birth. As a prescription drug, HCG offers us some interesting benefits.

For intramuscular use only. The dosage regimen employed in any particular case will depend upon the indication for the use, the age and weight of the patient, and the physician’s preference. The following regimens have been advocated by various authorities:
Prepubertal cryptorchidism not due to anatomical obstruction. Therapy is usually instituted in children between the ages of 4 and 9.
1. 4000 USP units 3 times weekly for 3 weeks.
2. 5000 USP units every second day for 4 injections.
3. 15 injections for 500 to 1000 USP units over a period of 6 weeks.
4. 500 USP units 3 times weekly for 4 to 6 weeks. If this course of treatment is not successful, another
series is begun 1 month later, giving 1000 USP units per injection.
Selected cases of hypogonadotropic hypogonadism in males.
1. 500 to 1000 USP units 3 times a week for 3 weeks, followed by the same dose twice a week for 3 weeks.
2. 4000 USP units 3 times weekly for 6 to 9 months, following which the dosage may be reduced to 2000 USP units 3 times weekly for an additional 3 months.
Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of
anovulation is secondary and not due to primary ovarian failure and who has been appropriately
pretreated with human menotropins. (See prescribing information for menotropins for dosage and administration for that drug product.)
5000 to 10,000 USP units 1 day following the last dose of menotropins. (A dosage of 10,000 USP units is recommended in the labeling for menotropins.)
This medication is given by injection into a muscle by a health care professional. If you are giving this medication at home, learn all preparation and usage instructions for this product. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If you have any questions about the use of this medication, ask your doctor or pharmacist.The dosage is based on your age, weight, medical condition, and response to treatment.For boys, use this medication usually 3 times a week or as directed by your doctor. For women, use this medication usually for 1 dose after finishing your menotropins treatment.Use this medication regularly to get the most benefit from it. To help you remember, mark the day(s) on the calendar when you need to receive the medication.Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.

SIDE EFFECTS: Headache, restlessness, tiredness, or pain at injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling of the ankles/feet, mental/mood changes (e.g., depression, irritability), signs of early puberty in boys (e.g., facial/pubic hair, voice change, acne), pain/swelling of the breast (in boys).For women, when this medication is used with menotropins to treat infertility, also tell your doctor immediately if this unlikely but serious side effect occurs: abdominal pain/pressure/swelling.For women, when this medication is used with menotropins to treat infertility, seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, slurred speech, weakness on one side of the body, confusion.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, shortness of breath.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: early puberty (in boys), male sex hormone-dependant cancer (e.g., prostate cancer) in boys.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., congestive heart failure), kidney disease, seizures, asthma, migraine headaches.This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately.When this medication is used in females with menotropins to treat infertility, it may cause multiple births (e.g., twins, triplets).It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS:
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: gonadorelin.This medication may interfere with certain laboratory tests (including luteinizing hormone-LH/follicle stimulating hormone-FSH levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

As discussed above, HCG acts only to mimic the action of LH. It is likewise not the perfect hormone to combat testosterone suppression, and for this reason it is used most often in conjunction with estrogen antagonists such as Clomid, Nolvadex or cyclofenil. These drugs have a different effect on the regulating system, namely inhibiting estrogen-induced suppression at the hypothalamus. This of course also helps to restore the release of testosterone, although through a much different mechanism than HCG. A combination of both drugs appears to be very synergistic, HCG providing an immediate effect on the testes (shocking them out of inactivity) while the anti-estrogen helps later to block inhibition on the hypothalamus and resume the normal release of gonadotropins from the pituitary. The typical procedure involves giving the Clomid/Nolvadex dose from the start with HCG, but continuing it alone for a few weeks once HCG has been discontinued. This practice should effectively raise testosterone levels, which will hopefully remain stable once Clomid/Nolvadex have been discontinued. While unfortunately there is no way to retain all of the muscle gains produced by anabolic steroids, using ancillaries to restore a balanced hormonal state is the best way to minimize the loss felt with ending a cycle.

Presentation
IMPORTANT: USE COMPLETELY AFTER RECONSTITUTION. RECONSTITUTED
SOLUTION IS STABLE FOR 60 DAYS WHEN REFRIGERATED.

Two-vial package containing: Rx only
1-10 mL lyophilized multiple dose vial containing: 10,000 USP units chorionic gonadotropin per vial,
1-10 mL vial of solvent containing: water for injection with sodium chloride 0.56% and
benzyl alcohol 0.9%, 
When reconstituted, each 10 mL vial contains:
Chorionic gonadotropin .................................10,000 USP units
Monobasic sodium phosphate.......................................... 5 mg
Dibasic sodium phosphate .............................................4.4 mg
Sodium chloride.............................................................. 0.56%
Benzyl alcohol.................................................................... 0.9%

If required pH adjusted with sodium hydroxide and/or phosphoric acid.
Storage: Store at controlled room temperature 15-30°C (59-86°F). Reconstituted solution is stable for 60 days when refrigerated.
 

Note : This product information is intended only for residents of the India. Taj Pharmaceuticals Limited,  medicines help to treat and prevent a range of conditions—from the most common to the most challenging—for people around the world.

Information for Health Care Professionals

*** Please consult local Prescribing Information for any product before use. This website is an international information resource for healthcare professionals with an interest in disease management. This website is not intended to replace the advice of a qualified healthcare professional. Above brand is a trademark of the Taj group of companies (Taj Pharmaceuticals Limited).

GENERIC NAME: GONADOTROPINS, CHORIONIC - INTRAMUSCULAR (GO-nad-oh-TROW-pins, ko-ree-ON-ick)
 

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Human chorionic gonadotropin (HCG) is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation. HCG is used to cause ovulation and to treat infertility in women, and to increase sperm count in men.

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